TXNIP Blocking Peptide(N-term)

Background:
TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Other Names:
Thioredoxin-interacting protein, Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1, TXNIP, VDUP1

Target/Specificity:
The synthetic peptide sequence is selected from aa 14-27 of HUMAN TXNIP

Gene Name: TXNIP

Gene ID: 10628
Primary Accession: Q9H3M7
Other Accession: Q5M7W1; Q8BG60; NP_006463.3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.