TYMS antibody (clone 3A1), anti-human

Background:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Other Names:
Thymidylate synthase, TS, TSase, TYMS, TS

Antigen Type:
Recombinant Protein

Gene Name: TYMS (HGNC:12441)
Gene ID: 7298
NCBI Accession: NP_001062.1
Primary Accession: P04818
Other Accession: BC013919
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .