Tyr-Specific Protein Kinase Inhibitor Peptide

Protein Family: Protein Kinases, Enzymes

Pathway and Disease: Signal Transduction, Cell Communication, Infectious Diseases

Alternate Names: Proto-oncogene tyrosine-protein kinase Src; p60-Src; c-Src; pp60c-src; SRC; SRC1

Accession No.: P12931

Description:
This peptide is an inhibitor for tyrosine protein kinases such as EGFR and Src subfamily members (IC50 = 7.5 mM for pp60 v-src). The sequence corresponds to residues 140-160 of the proto-oncogene tyrosine protein kinase Src (c-Src).

Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.

MW: 2482.8 g/mol

Sequence:
Val-Ala-Pro-Ser-Asp-Ser-Ile-Gln-Ala-Glu-Glu-Trp-Tyr-Phe-Gly-Lys-Ile-Thr-Arg-Arg-Glu or VAPSDSIQAEEWYFGKITRRE

Composition:
C111H168N30O33

Purity:
> 95% by HPLC

Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.

Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.