TYSY Antibody (C-term) Blocking Peptide

Background:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Other Names:
Thymidylate synthase, TS, TSase, TYMS, TS

Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6682b was selected from the C-term region of human TYSY. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Gene Name: TYMS (HGNC:12441)

Gene ID: 7298
Primary Accession: P04818
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.