TYSY Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP6682c
Background:
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
Other Names:
Thymidylate synthase, TS, TSase, TYMS, TS
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6682c was selected from the Center region of human TYSY. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TYMS (HGNC:12441)
Gene ID: 7298
Primary Accession: P04818
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
Other Names:
Thymidylate synthase, TS, TSase, TYMS, TS
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6682c was selected from the Center region of human TYSY. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TYMS (HGNC:12441)
Gene ID: 7298
Primary Accession: P04818
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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