UACA / Nucling (Nuclear Membrane Marker) (clone AE-5 ), anti-human, mouse
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In stock
SKU
AC-AH12110
Catalog Number: AC-AH12110
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: AE-5
Applications: WB, IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: AE-5
Applications: WB, IF, FC
Datasheet
Request Information
Background:
UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
Other Names:
Uveal autoantigen with coiled-coil domains and ankyrin repeats, UACA, KIAA1561
Gene Name: UACA
Gene ID: 55075
Primary Accession: Q9BZF9
Other Accession: 55075, 108049
UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.
Other Names:
Uveal autoantigen with coiled-coil domains and ankyrin repeats, UACA, KIAA1561
Gene Name: UACA
Gene ID: 55075
Primary Accession: Q9BZF9
Other Accession: 55075, 108049
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