UACA / Nucling (Nuclear Membrane Marker) (clone UACA/1222 ), anti-human, mouse

Background:
UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.

Other Names:
Uveal autoantigen with coiled-coil domains and ankyrin repeats, UACA, KIAA1561

Gene Name: UACA
Gene ID: 55075
Primary Accession: Q9BZF9
Other Accession: 55075, 108049