UBA1/Ube1 monoclonal, anti-human, mouse, rat
€455.00
In stock
SKU
AC-ABO13481
Catalog Number: AC-ABO13481
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC, FC
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC, IF, ICC, FC
Datasheet
Request Information
Description: Anti-UBA1/Ube1 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Protein Function:
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation- induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334)..
Other Names: Ubiquitin-like modifier-activating enzyme 1, 6.2.1.45, Protein A1S9, Ubiquitin-activating enzyme E1, UBA1, A1S9T, UBE1
Clone Name(s):
Clone: IAC-21
Subcellular Localization: Cytoplasm. Mitochondrion. Nucleus.
Tissue Specificity: Detected in erythrocytes (at protein level). Ubiquitous..
Gene ID: 7317
Immunogen: A synthesized peptide derived from human UBA1
Calculated MW: 117849
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation- induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334)..
Other Names: Ubiquitin-like modifier-activating enzyme 1, 6.2.1.45, Protein A1S9, Ubiquitin-activating enzyme E1, UBA1, A1S9T, UBE1
Clone Name(s):
Clone: IAC-21
Subcellular Localization: Cytoplasm. Mitochondrion. Nucleus.
Tissue Specificity: Detected in erythrocytes (at protein level). Ubiquitous..
Gene ID: 7317
Immunogen: A synthesized peptide derived from human UBA1
Calculated MW: 117849
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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