UBB Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP13217a
Background:
This gene encodes ubiquitin, one of the most conservedproteins known. Ubiquitin is required for ATP-dependent,nonlysosomal intracellular protein degradation of abnormal proteinsand normal proteins with a rapid turnover. Ubiquitin is covalentlybound to proteins to be degraded, and presumably labels theseproteins for degradation. Ubiquitin also binds to histone H2A inactively transcribed regions but does not cause histone H2Adegradation, suggesting that ubiquitin is also involved inregulation of gene expression. This gene consists of three directrepeats of the ubiquitin coding sequence with no spacer sequence.Consequently, the protein is expressed as a polyubiquitin precursorwith a final amino acid after the last repeat. Aberrant form ofthis protein has been noticed in patients with Alzheimer's and Downsyndrome.
Other Names:
Polyubiquitin-B, Ubiquitin, UBB
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13217a was selected from the N-term region of UBB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: UBB
Gene ID: 7314
Primary Accession: P0CG47
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes ubiquitin, one of the most conservedproteins known. Ubiquitin is required for ATP-dependent,nonlysosomal intracellular protein degradation of abnormal proteinsand normal proteins with a rapid turnover. Ubiquitin is covalentlybound to proteins to be degraded, and presumably labels theseproteins for degradation. Ubiquitin also binds to histone H2A inactively transcribed regions but does not cause histone H2Adegradation, suggesting that ubiquitin is also involved inregulation of gene expression. This gene consists of three directrepeats of the ubiquitin coding sequence with no spacer sequence.Consequently, the protein is expressed as a polyubiquitin precursorwith a final amino acid after the last repeat. Aberrant form ofthis protein has been noticed in patients with Alzheimer's and Downsyndrome.
Other Names:
Polyubiquitin-B, Ubiquitin, UBB
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13217a was selected from the N-term region of UBB. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: UBB
Gene ID: 7314
Primary Accession: P0CG47
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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