UBE1L (clone 5B10), anti-human
€478.00
In stock
SKU
253054
Protein Family: Enzymes
Pathway and Disease: Amino Acid Metabolism
Description:
UBE1L (Ubiquitin-activating enzyme E1 homolog UBE1L) a member of the E1 ubiquitin-activating enzyme family. Modification of proteins with ubiquitin is an important cellular mechanism for targeting. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases or E3s. UBE1L is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. UBE1L is expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation.
Alternate Names: Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-activating enzyme 7, D8, Ubiquitin-activating enzyme E1 homolog UBE1L, UBE2, UBA7
Application Notes: WB: 1:500-1:2000
Accession No.: P41226
Antigen: Purified recombinant fragment of human UBE1L expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Amino Acid Metabolism
Description:
UBE1L (Ubiquitin-activating enzyme E1 homolog UBE1L) a member of the E1 ubiquitin-activating enzyme family. Modification of proteins with ubiquitin is an important cellular mechanism for targeting. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases or E3s. UBE1L is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. UBE1L is expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation.
Alternate Names: Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-activating enzyme 7, D8, Ubiquitin-activating enzyme E1 homolog UBE1L, UBE2, UBA7
Application Notes: WB: 1:500-1:2000
Accession No.: P41226
Antigen: Purified recombinant fragment of human UBE1L expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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