UBE2A/UBE2B polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61735
Background:
The ubiquitin-conjugating (UBC) enzymes HR6A and HR6B are the mammalian orthologues of the Saccharomyces cerevisiae Rad6 gene products. In S. cerevisiae, Rad6 facilitates cell cycle progression and ubiquitinates histone H2B. In vivo phosphorylation of HR6A Ser120 by cyclin-dependent kinases is thought to be important for the coordination and timing of ubiquitination events involved in cell cycle progression. In response to DNA damage, HR6A is known to interact physically with p53 and p14ARF, but knockout mice lacking HR6A or HR6B exhibit normal DNA damage responses. HR6B knockout males exhibit defective spermatogenesis, while HR6A knockout females fail to produce viable offspring.
Alternative Name:
Ubiquitin-conjugating enzyme E2 A, E2 ubiquitin-conjugating enzyme A, RAD6 homolog A, HR6A, hHR6A, Ubiquitin carrier protein A, Ubiquitin-protein ligase A, UBE2A, RAD6A, Ubiquitin-conjugating enzyme E2 B, E2 ubiquitin-conjugating enzyme B, RAD6 homolog B, HR6B, hHR6B, Ubiquitin carrier protein B, Ubiquitin-conjugating enzyme E2-17 kDa, Ubiquitin-protein ligase B, UBE2B, RAD6B
Application Dilution: WB: 1:500~1:1000
Specificity: UBE2A/UBE2B polyclonal antibody detects endogenous levels of UBE2A/UBE2B protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 100-150 of Human UBE2A/UBE2B.
MW: ~ 17 kDa
Swis Prot.: P49459/P63146
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The ubiquitin-conjugating (UBC) enzymes HR6A and HR6B are the mammalian orthologues of the Saccharomyces cerevisiae Rad6 gene products. In S. cerevisiae, Rad6 facilitates cell cycle progression and ubiquitinates histone H2B. In vivo phosphorylation of HR6A Ser120 by cyclin-dependent kinases is thought to be important for the coordination and timing of ubiquitination events involved in cell cycle progression. In response to DNA damage, HR6A is known to interact physically with p53 and p14ARF, but knockout mice lacking HR6A or HR6B exhibit normal DNA damage responses. HR6B knockout males exhibit defective spermatogenesis, while HR6A knockout females fail to produce viable offspring.
Alternative Name:
Ubiquitin-conjugating enzyme E2 A, E2 ubiquitin-conjugating enzyme A, RAD6 homolog A, HR6A, hHR6A, Ubiquitin carrier protein A, Ubiquitin-protein ligase A, UBE2A, RAD6A, Ubiquitin-conjugating enzyme E2 B, E2 ubiquitin-conjugating enzyme B, RAD6 homolog B, HR6B, hHR6B, Ubiquitin carrier protein B, Ubiquitin-conjugating enzyme E2-17 kDa, Ubiquitin-protein ligase B, UBE2B, RAD6B
Application Dilution: WB: 1:500~1:1000
Specificity: UBE2A/UBE2B polyclonal antibody detects endogenous levels of UBE2A/UBE2B protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 100-150 of Human UBE2A/UBE2B.
MW: ~ 17 kDa
Swis Prot.: P49459/P63146
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review