UBE2O polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS70834
Background:
UBE20 (ubiquitin-conjugating enzyme E2O), also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.
Alternative Name:
KIAA1734, Ubiquitin-protein ligase O, (E3-independent) E2 ubiquitin-conjugating enzyme
Application Dilution: WB: 1:1000 - 1:4000, IP 1:50 - 1:100
Specificity: UBE2O polyclonal antibody detects endogenous levels of UBE2O protein.
Immunogen:
Recombinant protein of human UBE2O.
MW: ~ 141 kDa
Swis Prot.: Q9C0C9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
UBE20 (ubiquitin-conjugating enzyme E2O), also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.
Alternative Name:
KIAA1734, Ubiquitin-protein ligase O, (E3-independent) E2 ubiquitin-conjugating enzyme
Application Dilution: WB: 1:1000 - 1:4000, IP 1:50 - 1:100
Specificity: UBE2O polyclonal antibody detects endogenous levels of UBE2O protein.
Immunogen:
Recombinant protein of human UBE2O.
MW: ~ 141 kDa
Swis Prot.: Q9C0C9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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