UBE3A antibody (clone 2F6), anti-human, rat
€435.00
In stock
SKU
AC-AT4445a
Catalog Number: AC-AT4445a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF, Ehttps://www.abcepta.com/products/pdf_download/AT4445a-UBE3A-Antibody-monoclonal-M01">Request Information AC-AT4445a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF, Ehttps://www.abcepta.com/products/pdf_download/AT4445a-UBE3A-Antibody-monoclonal-M01">Request Information AC-AT4445a">Request Information
Background:
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Other Names:
Ubiquitin-protein ligase E3A, 632-, E6AP ubiquitin-protein ligase, Human papillomavirus E6-associated protein, Oncogenic protein-associated protein E6-AP, Renal carcinoma antigen NY-REN-54, UBE3A, E6AP, EPVE6AP, HPVE6A
Antigen Type:
Recombinant Protein
Gene Name: UBE3A (HGNC:12496)
Gene ID: 7337
NCBI Accession: NP_000453.2;NP_570853.1;NP_570854.1
Primary Accession: Q05086
Other Accession: BC009271
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Other Names:
Ubiquitin-protein ligase E3A, 632-, E6AP ubiquitin-protein ligase, Human papillomavirus E6-associated protein, Oncogenic protein-associated protein E6-AP, Renal carcinoma antigen NY-REN-54, UBE3A, E6AP, EPVE6AP, HPVE6A
Antigen Type:
Recombinant Protein
Gene Name: UBE3A (HGNC:12496)
Gene ID: 7337
NCBI Accession: NP_000453.2;NP_570853.1;NP_570854.1
Primary Accession: Q05086
Other Accession: BC009271
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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