UBE3A Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14799a
Background:
This gene encodes an E3 ubiquitin-protein ligase, part ofthe ubiquitin protein degradation system. This imprinted gene ismaternally expressed in brain and biallelically expressed in othertissues. Maternally inherited deletion of this gene causes AngelmanSyndrome, characterized by severe motor and intellectualretardation, ataxia, hypotonia, epilepsy, absence of speech, andcharacteristic facies. The protein also interacts with the E6protein of human papillomavirus types 16 and 18, resulting inubiquitination and proteolysis of tumor protein p53. Alternativesplicing of this gene results in three transcript variants encodingthree isoforms with different N-termini. Additional transcriptvariants have been described, but their full length nature has notbeen determined.
Other Names:
Ubiquitin-protein ligase E3A, 632-, E6AP ubiquitin-protein ligase, Human papillomavirus E6-associated protein, Oncogenic protein-associated protein E6-AP, Renal carcinoma antigen NY-REN-54, UBE3A, E6AP, EPVE6AP, HPVE6A
Gene Name: UBE3A (HGNC:12496)
Gene ID: 7337
Primary Accession: Q05086
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes an E3 ubiquitin-protein ligase, part ofthe ubiquitin protein degradation system. This imprinted gene ismaternally expressed in brain and biallelically expressed in othertissues. Maternally inherited deletion of this gene causes AngelmanSyndrome, characterized by severe motor and intellectualretardation, ataxia, hypotonia, epilepsy, absence of speech, andcharacteristic facies. The protein also interacts with the E6protein of human papillomavirus types 16 and 18, resulting inubiquitination and proteolysis of tumor protein p53. Alternativesplicing of this gene results in three transcript variants encodingthree isoforms with different N-termini. Additional transcriptvariants have been described, but their full length nature has notbeen determined.
Other Names:
Ubiquitin-protein ligase E3A, 632-, E6AP ubiquitin-protein ligase, Human papillomavirus E6-associated protein, Oncogenic protein-associated protein E6-AP, Renal carcinoma antigen NY-REN-54, UBE3A, E6AP, EPVE6AP, HPVE6A
Gene Name: UBE3A (HGNC:12496)
Gene ID: 7337
Primary Accession: Q05086
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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