UBE4A Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP2110a
Background:
Ubiquitination requires a ubiquitin-activating enzyme, a ubiquitin-conjugating enzyme, and usually a substrate-specific ubiquitin-protein ligase. Multiubiquitination needs a fourth factor, to bind to the ubiquitin moieties of preformed conjugates and catalyze ubiquitin chain assembly in conjunction with the first three proteins.1 Human protein KIAA0126, with a predicted 1,073 amino acid residues, is a member of the novel protein family defined by ubiquitination conjugation factor E4.2 In yeast, E4 activity is linked to cell survival under stress conditions, indicating that eucaryotes use E4-dependent proteolysis pathways for multiple cellular functions.
Other Names:
Ubiquitin conjugation factor E4 A, 632-, UBE4A (HGNC:12499)
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2110a was selected from the N-term region of human UBE4A . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: UBE4A (HGNC:12499)
Gene ID: 9354
Primary Accession: Q14139
Other Accession: NP_004779
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Ubiquitination requires a ubiquitin-activating enzyme, a ubiquitin-conjugating enzyme, and usually a substrate-specific ubiquitin-protein ligase. Multiubiquitination needs a fourth factor, to bind to the ubiquitin moieties of preformed conjugates and catalyze ubiquitin chain assembly in conjunction with the first three proteins.1 Human protein KIAA0126, with a predicted 1,073 amino acid residues, is a member of the novel protein family defined by ubiquitination conjugation factor E4.2 In yeast, E4 activity is linked to cell survival under stress conditions, indicating that eucaryotes use E4-dependent proteolysis pathways for multiple cellular functions.
Other Names:
Ubiquitin conjugation factor E4 A, 632-, UBE4A (HGNC:12499)
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2110a was selected from the N-term region of human UBE4A . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: UBE4A (HGNC:12499)
Gene ID: 9354
Primary Accession: Q14139
Other Accession: NP_004779
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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