UBR1 Blocking Peptide (N-term)

Background:
The N-end rule pathway is one proteolytic pathway of theubiquitin system. The recognition component of this pathway,encoded by this gene, binds to a destabilizing N-terminal residueof a substrate protein and participates in the formation of asubstrate-linked multiubiquitin chain. This leads to the eventualdegradation of the substrate protein. The protein described in thisrecord has a RING-type zinc finger and a UBR-type zinc finger.Mutations in this gene have been associated with Johanson-Blizzardsyndrome.

Other Names:
E3 ubiquitin-protein ligase UBR1, 632-, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1

Target/Specificity:
The synthetic peptide sequence is selected from aa 260-274 of HUMAN UBR1

Gene Name: UBR1 {ECO:0000303|PubMed:15317757, ECO:0000312|HGNC:HGNC:16808}

Gene ID: 197131
Primary Accession: Q8IWV7
Other Accession: O70481; NP_777576.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.