UCHL1 polyclonal, anti-human, mouse
€442.00
In stock
SKU
253235
Catalog Nr.: 253235
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB, IF, IHC
Datasheet
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Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB, IF, IHC
Datasheet
Request Information
Protein Family: Enzymes, Peptidases
Pathway and Disease: Neurodegenerative Disorders
Description:
Ubiquitin C-terminal hydrolase 1 (UCHL1) cleaves ubiquitin from other molecules. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration. The detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
Alternate Names: Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1, UCHL1
Application Notes: E: 1:10,000; WB: 1:5,000; IF: 1:500; IHC: 1:500
Accession No.: P09936
Antigen: Recombinant full length human UCHL1 expressed in E. coli.
Format: Each vial contains 0.1 ml concentrated culture supernatant with 0.065% sodium azide.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Neurodegenerative Disorders
Description:
Ubiquitin C-terminal hydrolase 1 (UCHL1) cleaves ubiquitin from other molecules. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration. The detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.
Alternate Names: Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1, UCHL1
Application Notes: E: 1:10,000; WB: 1:5,000; IF: 1:500; IHC: 1:500
Accession No.: P09936
Antigen: Recombinant full length human UCHL1 expressed in E. coli.
Format: Each vial contains 0.1 ml concentrated culture supernatant with 0.065% sodium azide.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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