UHRF1 polyclonal (ChIP Grade), anti-human
€388.00
In stock
SKU
BS7227
Background:
UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin-protein ligase. It may participate in methylation-dependent transcriptional regulation. UHRF1 binds to inverted 5-CCAAT-3 box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1s ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2.
Alternative Name:
E3 ubiquitin-protein ligase UHRF1, Nuclear protein 95, Nuclear zinc finger protein Np95, HuNp95, hNp95, RING finger protein 106, Transcription factor ICBP90, hUHRF1, ICBP90, NP95, RNF106
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: UHRF1 polyclonal antibody detects endogenous levels of UHRF1 protein.
Immunogen:
Recombinant full length Human UHRF1.
MW: ~ 90, 110 kDa
Swis Prot.: Q96T88
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin-protein ligase. It may participate in methylation-dependent transcriptional regulation. UHRF1 binds to inverted 5-CCAAT-3 box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1s ability to repress its direct target gene expression is dependent on PHD(UHRF1) binding to unmodified H3R2.
Alternative Name:
E3 ubiquitin-protein ligase UHRF1, Nuclear protein 95, Nuclear zinc finger protein Np95, HuNp95, hNp95, RING finger protein 106, Transcription factor ICBP90, hUHRF1, ICBP90, NP95, RNF106
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: UHRF1 polyclonal antibody detects endogenous levels of UHRF1 protein.
Immunogen:
Recombinant full length Human UHRF1.
MW: ~ 90, 110 kDa
Swis Prot.: Q96T88
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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