ULBP2 polyclonal, anti-mouse, rat
€388.00
In stock
SKU
BS71139
Background:
Cytomegalovirus UL16 binding proteins, known as ULBPs, are GPI-linked glycoproteins that belong to the extended MHC class I family. ULBP proteins are ligands for the activating receptor, NKG2D/DAP10, which causes lymphocyte activation, resulting in the secretion of cytokines, such as interferon-gamma and tumor cell lysis. ULBPs stimulate cytokine and chemokine production from NK cells, CD8 alpha/beta T cells, and gamma/delta T cells. UL16, binds to three of the five known ligands for human NKG2D. UL16 is retained in the endoplasmic reticulum and cis-Golgi apparatus of cells and causes MICB to be similarly retained and stabilized within cells. Coexpression of UL16 markedly reduces cell surface levels of MICB, ULBP1, and ULBP2, and decreases susceptibility to natural killer cell-mediated cytotoxicity.
Alternative Name:
N2DL2, RAET1H, NKG2DL2, ALCAN-alpha,
Application Dilution: WB: 1:500 - 1:2000
Specificity: ULBP2 polyclonal antibody detects endogenous levels of ULBP2 protein.
Immunogen:
Recombinant protein of human ULBP2.
MW: ~ 27 kDa
Swis Prot.: Q9BZM5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cytomegalovirus UL16 binding proteins, known as ULBPs, are GPI-linked glycoproteins that belong to the extended MHC class I family. ULBP proteins are ligands for the activating receptor, NKG2D/DAP10, which causes lymphocyte activation, resulting in the secretion of cytokines, such as interferon-gamma and tumor cell lysis. ULBPs stimulate cytokine and chemokine production from NK cells, CD8 alpha/beta T cells, and gamma/delta T cells. UL16, binds to three of the five known ligands for human NKG2D. UL16 is retained in the endoplasmic reticulum and cis-Golgi apparatus of cells and causes MICB to be similarly retained and stabilized within cells. Coexpression of UL16 markedly reduces cell surface levels of MICB, ULBP1, and ULBP2, and decreases susceptibility to natural killer cell-mediated cytotoxicity.
Alternative Name:
N2DL2, RAET1H, NKG2DL2, ALCAN-alpha,
Application Dilution: WB: 1:500 - 1:2000
Specificity: ULBP2 polyclonal antibody detects endogenous levels of ULBP2 protein.
Immunogen:
Recombinant protein of human ULBP2.
MW: ~ 27 kDa
Swis Prot.: Q9BZM5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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