UMPS antibody (clone 2B10), anti-human

Background:
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

Other Names:
Uridine 5'-monophosphate synthase, UMP synthase, Orotate phosphoribosyltransferase, OPRT, OPRTase, Orotidine 5'-phosphate decarboxylase, ODC, OMPdecase, UMPS

Antigen Type:
Recombinant Protein

Gene Name: UMPS (HGNC:12563)
Gene ID: 7372
NCBI Accession: NP_000364.1
Primary Accession: P11172
Other Accession: NM_000373
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .