UNC13D polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS72432
Background:
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Alternative Name:
FHL3,HLH3,HPLH3,Munc13-4
Application Dilution: WB: 1:1000 - 1:2000
Specificity: UNC13D polyclonal antibody detects endogenous levels of UNC13D protein.
Immunogen:
Recombinant protein of human UNC13D
MW: ~ 128 kDa
Swis Prot.: Q70J99
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Alternative Name:
FHL3,HLH3,HPLH3,Munc13-4
Application Dilution: WB: 1:1000 - 1:2000
Specificity: UNC13D polyclonal antibody detects endogenous levels of UNC13D protein.
Immunogen:
Recombinant protein of human UNC13D
MW: ~ 128 kDa
Swis Prot.: Q70J99
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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