UPF3A Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP12579c
Background:
This gene encodes a protein that is part of apost-splicing multiprotein complex involved in both mRNA nuclearexport and mRNA surveillance. The encoded protein is one of twofunctional homologs to yeast Upf3p. mRNA surveillance detectsexported mRNAs with truncated open reading frames and initiatesnonsense-mediated mRNA decay (NMD). When translation ends upstreamfrom the last exon-exon junction, this triggers NMD to degrademRNAs containing premature stop codons. This protein binds to themRNA and remains bound after nuclear export, acting as anucleocytoplasmic shuttling protein. It forms with Y14 a complexthat binds specifically 20 nt upstream of exon-exon junctions. Thisgene is located on the long arm of chromosome 13. Two splicevariants encoding different isoforms have been found for this gene.
Other Names:
Regulator of nonsense transcripts 3A, Nonsense mRNA reducing factor 3A, Up-frameshift suppressor 3 homolog A, hUpf3, UPF3A, RENT3A, UPF3
Gene Name: UPF3A
Gene ID: 65110
Primary Accession: Q9H1J1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a protein that is part of apost-splicing multiprotein complex involved in both mRNA nuclearexport and mRNA surveillance. The encoded protein is one of twofunctional homologs to yeast Upf3p. mRNA surveillance detectsexported mRNAs with truncated open reading frames and initiatesnonsense-mediated mRNA decay (NMD). When translation ends upstreamfrom the last exon-exon junction, this triggers NMD to degrademRNAs containing premature stop codons. This protein binds to themRNA and remains bound after nuclear export, acting as anucleocytoplasmic shuttling protein. It forms with Y14 a complexthat binds specifically 20 nt upstream of exon-exon junctions. Thisgene is located on the long arm of chromosome 13. Two splicevariants encoding different isoforms have been found for this gene.
Other Names:
Regulator of nonsense transcripts 3A, Nonsense mRNA reducing factor 3A, Up-frameshift suppressor 3 homolog A, hUpf3, UPF3A, RENT3A, UPF3
Gene Name: UPF3A
Gene ID: 65110
Primary Accession: Q9H1J1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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