USP5 monoclonal, anti-human, mouse, rat
€0.00
In stock
SKU
AC-AM8423b
Catalog Number: AC-AM8423b
Size: 80 µl, 400 µl
Isotype: mouse IgG1,κ
Clone Name: 1340CT704.170.140
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG1,κ
Clone Name: 1340CT704.170.140
Applications: WB
Datasheet
Request Information
Background:
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Other Names:
Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, ISOT
Target/Specificity:
This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.
Antigen Type: Recombinant Protein
Gene Name: USP5
Gene ID: 8078
Primary Accession: P45974
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Other Names:
Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, ISOT
Target/Specificity:
This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.
Antigen Type: Recombinant Protein
Gene Name: USP5
Gene ID: 8078
Primary Accession: P45974
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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