USP6NL polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61476
Background:
GTPase-activating proteins(GAPs) accelerate the intrinsicrate of GTP hydroysis of Ras-related proteins, resulting in downregulation of their active form.RN-tre (related to the N-terminus of tre), also known as USP6NL(USP6 Nterminal like) or TRE2NL, is an 828 amino acid protein thatcontains one RabGAP TBC domain. Expressed in awide variety of tissues, RN-tre functions as a GTPase-activating protein for Rab 5A and isthought to be involved in receptor trafficking, aswell asin the inhibition of EGFR internalization. In response to DNA damage, RN-tre may be phosphorylated by ATM or ATR. The gene encoding RN-tre mapsto human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
Alternative Name:
USP6 N-terminal-like protein, Related to the N-terminus of tre, RN-tre, USP6NL, KIAA0019
Application Dilution: WB: 1:500~1:1000
Specificity: USP6NL polyclonal antibody detects endogenous levels of USP6NL protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 446-491 of Human USP6NL.
MW: ~ 86 kDa
Swis Prot.: Q92738
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
GTPase-activating proteins(GAPs) accelerate the intrinsicrate of GTP hydroysis of Ras-related proteins, resulting in downregulation of their active form.RN-tre (related to the N-terminus of tre), also known as USP6NL(USP6 Nterminal like) or TRE2NL, is an 828 amino acid protein thatcontains one RabGAP TBC domain. Expressed in awide variety of tissues, RN-tre functions as a GTPase-activating protein for Rab 5A and isthought to be involved in receptor trafficking, aswell asin the inhibition of EGFR internalization. In response to DNA damage, RN-tre may be phosphorylated by ATM or ATR. The gene encoding RN-tre mapsto human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
Alternative Name:
USP6 N-terminal-like protein, Related to the N-terminus of tre, RN-tre, USP6NL, KIAA0019
Application Dilution: WB: 1:500~1:1000
Specificity: USP6NL polyclonal antibody detects endogenous levels of USP6NL protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 446-491 of Human USP6NL.
MW: ~ 86 kDa
Swis Prot.: Q92738
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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