UVRAG polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71241
Background:
UVRAG (UV radiation resistance-associated gene), also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells.
Alternative Name:
p63, DHTX, VPS38,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: UVRAG polyclonal antibody detects endogenous levels of UVRAG protein.
Immunogen:
Recombinant protein of human UVRAG.
MW: ~ 78 kDa
Swis Prot.: Q9P2Y5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
UVRAG (UV radiation resistance-associated gene), also known as p63 or DHTX, is a 699 amino acid cytoplasmic protein. UVRAG has been shown to activate the BECN1/PI 3-kinase complex, which promotes autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Mutations in the gene encoding UVRAG have been associated with colon cancer, suggesting that UVRAG is also involved in suppressing the proliferation and tumorigenicity of human colon cancer cells. UVRAG has been found to complement the ultraviolet sensitivity of xeroderma pigmentosum group C cells.
Alternative Name:
p63, DHTX, VPS38,
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: UVRAG polyclonal antibody detects endogenous levels of UVRAG protein.
Immunogen:
Recombinant protein of human UVRAG.
MW: ~ 78 kDa
Swis Prot.: Q9P2Y5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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