VASP Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13999b
Background:
Vasodilator-stimulated phosphoprotein (VASP) is a memberof the Ena-VASP protein family. Ena-VASP family members contain anEHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/Emotifs and targets Ena-VASP proteins to focal adhesions. In themid-region of the protein, family members have a proline-richdomain that binds SH3 and WW domain-containing proteins. TheirC-terminal EVH2 domain mediates tetramerization and binds both Gand F actin. VASP is associated with filamentous actin formationand likely plays a widespread role in cell adhesion and motility.VASP may also be involved in the intracellular signaling pathwaysthat regulate integrin-extracellular matrix interactions. VASP isregulated by the cyclic nucleotide-dependent kinases PKA and PKG.
Other Names:
Vasodilator-stimulated phosphoprotein, VASP, VASP
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13999b was selected from the C-term region of VASP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: VASP
Gene ID: 7408
Primary Accession: P50552
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Vasodilator-stimulated phosphoprotein (VASP) is a memberof the Ena-VASP protein family. Ena-VASP family members contain anEHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/Emotifs and targets Ena-VASP proteins to focal adhesions. In themid-region of the protein, family members have a proline-richdomain that binds SH3 and WW domain-containing proteins. TheirC-terminal EVH2 domain mediates tetramerization and binds both Gand F actin. VASP is associated with filamentous actin formationand likely plays a widespread role in cell adhesion and motility.VASP may also be involved in the intracellular signaling pathwaysthat regulate integrin-extracellular matrix interactions. VASP isregulated by the cyclic nucleotide-dependent kinases PKA and PKG.
Other Names:
Vasodilator-stimulated phosphoprotein, VASP, VASP
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13999b was selected from the C-term region of VASP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: VASP
Gene ID: 7408
Primary Accession: P50552
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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