Vav (phospho Tyr174) Polyclonal Antibody

Background:
vav guanine nucleotide exchange factor 1(VAV1) Homo sapiens This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],

Alternative Names:
VAV1, VAV, Proto-oncogene vav

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human Vav (phospho Tyr174)

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 100

GeneID: VAV1

Storage: -20°C/1 year

NOTE: For Research Use Only