VAV1 antibody (clone 3A11), anti-human
€435.00
In stock
SKU
AC-AT4503a
Catalog Number: AC-AT4503a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
Request Information AC-AT4503a">Request Information
Background:
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Other Names:
Proto-oncogene vav, VAV1, VAV
Antigen Type:
Recombinant Protein
Gene Name: VAV1
Gene ID: 7409
NCBI Accession: NP_001245136.1;NP_005419.2
Primary Accession: P15498
Other Accession: BC013361
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Other Names:
Proto-oncogene vav, VAV1, VAV
Antigen Type:
Recombinant Protein
Gene Name: VAV1
Gene ID: 7409
NCBI Accession: NP_001245136.1;NP_005419.2
Primary Accession: P15498
Other Accession: BC013361
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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