VCL antibody (clone 2C6-1B5), anti-human

Background:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Other Names:
Vinculin, Metavinculin, MV, VCL

Antigen Type:
Recombinant Protein

Gene Name: VCL
Gene ID: 7414
NCBI Accession: NP_003364.1;NP_054706.1
Primary Accession: P18206
Other Accession: BC039174
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .