VCL polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS72447
Background:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Alternative Name:
CMD1W,CMH15,HEL114,MV,MVCL
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: VCL polyclonal antibody detects endogenous levels of VCL protein.
Immunogen:
Recombinant protein of human VCL
MW: ~ 130 kDa
Swis Prot.: P18206
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Alternative Name:
CMD1W,CMH15,HEL114,MV,MVCL
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: VCL polyclonal antibody detects endogenous levels of VCL protein.
Immunogen:
Recombinant protein of human VCL
MW: ~ 130 kDa
Swis Prot.: P18206
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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