VDR antibody (clone 2F4), anti-human
€435.00
In stock
SKU
AC-AT4509a
Catalog Number: AC-AT4509a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: IHC, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: IHC, E
Request Information AC-AT4509a">Request Information
Background:
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Other Names:
Vitamin D3 receptor, VDR,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1
Antigen Type:
Recombinant Protein
Gene Name: VDR (HGNC:12679)
Gene ID: 7421
NCBI Accession: NP_000367.1;NP_001017535.1;NP_001017536.1
Primary Accession: P11473
Other Accession: BC060832
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Other Names:
Vitamin D3 receptor, VDR,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1
Antigen Type:
Recombinant Protein
Gene Name: VDR (HGNC:12679)
Gene ID: 7421
NCBI Accession: NP_000367.1;NP_001017535.1;NP_001017536.1
Primary Accession: P11473
Other Accession: BC060832
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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