VE-Cadherin Cdh5 monoclonal, anti-mouse

Description: Anti-VE-Cadherin Cdh5-Rabbit Monoclonal Antibody . Tested in WB, ICC/IF, IP applications. This antibody reacts with Mouse.

Protein Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction..

Other Names: Cadherin-5 {ECO:0000312|MGI:MGI:105057}, Vascular endothelial cadherin, VE-cadherin, CD144, Cdh5 {ECO:0000312|MGI:MGI:105057}

Clone Name(s):
Clone: IIC-3

Subcellular Localization: Cell junction. Cell membrane ; Single-pass type I membrane protein. Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions (By similarity)..

Gene ID: 12562

Immunogen: A synthesized peptide derived from mouse VE Cadherin

Calculated MW: 87903

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.