VHL antibody (clone 1G12), anti-human
€435.00
In stock
SKU
AC-AT4511a
Catalog Number: AC-AT4511a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IF, E
Request Information AC-AT4511a">Request Information
Background:
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Other Names:
Von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
Antigen Type:
Recombinant Protein
Gene Name: VHL
Gene ID: 7428
NCBI Accession: NP_000542.1;NP_937799.1
Primary Accession: P40337
Other Accession: NM_000551
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Other Names:
Von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
Antigen Type:
Recombinant Protein
Gene Name: VHL
Gene ID: 7428
NCBI Accession: NP_000542.1;NP_937799.1
Primary Accession: P40337
Other Accession: NM_000551
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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