Vitronectin (clone A27), anti-bovine, sheep

Protein Family: CAM Ligands, Receptors and Channels, Cell Adhesion Molecules

Pathway and Disease: Cancers, Signaling Molecules and Interaction, Cell Motility, Cell Growth and Death

Description:
Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognises fibronectin. This antibody is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). This antibody reacts with sheep and bovine vitronectin, but does not with human or horse.

Alternate Names: Vitronectin, Serum-spreading factor, S-protein, V75

Application Notes: Product Cat. No. 250267 is suitable for ELISA, immunoblotting and immunostaining of frozen PLP-fixed sections of bovine tissues. The antibody can be used as an affinity purification reagent of vitronectin from bovine plasma or serum and to quantitatively deplete plasma or serum of vitronectin. It can also be used to probe vitronectin conformation. E: 1:80,000; WB: 1:200; IHC: 1:50

Accession No.: P04004

Antigen: Lysed bovine corneal endothelial cells and extracellular matrix

Format: Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.