VRK1 Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP7408c
Background:
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Other Names:
Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1, VRK1
Target/Specificity:
The synthetic peptide is selected from the sequence of human VRK1 within aa 300-400.
Gene Name: VRK1 {ECO:0000303|PubMed:9344656, ECO:0000312|HGNC:HGNC:12718}
Gene ID: 7443
Primary Accession: Q99986
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Other Names:
Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1, VRK1
Target/Specificity:
The synthetic peptide is selected from the sequence of human VRK1 within aa 300-400.
Gene Name: VRK1 {ECO:0000303|PubMed:9344656, ECO:0000312|HGNC:HGNC:12718}
Gene ID: 7443
Primary Accession: Q99986
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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