VRK1 monoclonal (Center)(Ascites), anti-human

Background:
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm.

Other Names:
Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1, VRK1

Target/Specificity:
Purified His-tagged VRK1 protein was used to produced this monoclonal antibody.

Antigen Type: Recombinant Protein

Gene Name: VRK1 {ECO:0000303|PubMed:9344656, ECO:0000312|HGNC:HGNC:12718}
Gene ID: 7443
Primary Accession: Q99986
NCBI Accession: NP_003375.1
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.