WASL antibody (clone 5F4), anti-human
€435.00
In stock
SKU
AC-AT4527a
Catalog Number: AC-AT4527a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, IF
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, IHC, IF
Request Information AC-AT4527a">Request Information
Background:
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
Other Names:
Neural Wiskott-Aldrich syndrome protein, N-WASP, WASL
Antigen Type:
Recombinant Protein
Gene Name: WASL
Gene ID: 8976
NCBI Accession: NP_003932.3
Primary Accession: O00401
Other Accession: NM_003941
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
Other Names:
Neural Wiskott-Aldrich syndrome protein, N-WASP, WASL
Antigen Type:
Recombinant Protein
Gene Name: WASL
Gene ID: 8976
NCBI Accession: NP_003932.3
Primary Accession: O00401
Other Accession: NM_003941
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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