WDR5 (clone 7B11), anti-human
€478.00
In stock
SKU
253033
Protein Family: Transcription factors
Pathway and Disease: Transcription
Description:
WDR5 (WD repeat-containing protein 5) belongs to the family of WD-40 repeat protein. It is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.
Alternate Names: WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, BIG3, WDR5
Application Notes: WB: 1:200-1:1000
Accession No.: P61964
Antigen: Purified recombinant fragment of human WDR5 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Transcription
Description:
WDR5 (WD repeat-containing protein 5) belongs to the family of WD-40 repeat protein. It is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.
Alternate Names: WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, BIG3, WDR5
Application Notes: WB: 1:200-1:1000
Accession No.: P61964
Antigen: Purified recombinant fragment of human WDR5 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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