WEE2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61656
Background:
Wee1-like protein kinase 2,Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Alternative Name:
Wee1-like protein kinase 2, Wee1-like protein kinase 1B, Wee1B kinase, WEE2, WEE1B
Application Dilution: WB: 1:500~1:1000
Specificity: WEE2 polyclonal antibody detects endogenous levels of WEE2 protein.
Immunogen:
Synthetic peptide, corresponding Human WEE2.
MW: ~ 62 kDa
Swis Prot.: P0C1S8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Wee1-like protein kinase 2,Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Alternative Name:
Wee1-like protein kinase 2, Wee1-like protein kinase 1B, Wee1B kinase, WEE2, WEE1B
Application Dilution: WB: 1:500~1:1000
Specificity: WEE2 polyclonal antibody detects endogenous levels of WEE2 protein.
Immunogen:
Synthetic peptide, corresponding Human WEE2.
MW: ~ 62 kDa
Swis Prot.: P0C1S8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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