Wilms Tumor Protein WT1 monoclonal, anti-human, mouse

Description: Anti-Wilms Tumor Protein WT1 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse.

Protein Function:
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA..

Other Names: Wilms tumor protein, WT33, WT1

Clone Name(s):
Clone: CEH-23

Subcellular Localization: Nucleus. Nucleus, nucleolus. Cytoplasm. Shuttles between nucleus and cytoplasm..

Tissue Specificity: Expressed in the kidney and a subset of hematopoietic cells.

Gene ID: 7490

Immunogen: A synthesized peptide derived from human Wilms Tumor Protein

Calculated MW: 49188

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.