WISP2 antibody (clone 3D10), anti-human
€435.00
In stock
SKU
AC-AT4540a
Catalog Number: AC-AT4540a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IP
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IP
Request Information AC-AT4540a">Request Information
Background:
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Other Names:
WNT1-inducible-signaling pathway protein 2, WISP-2, CCN family member 5, Connective tissue growth factor-like protein, CTGF-L, Connective tissue growth factor-related protein 58, WISP2, CCN5, CT58, CTGFL
Antigen Type:
Recombinant Protein
Gene Name: CCN5 (HGNC:12770)
Gene ID: 8839
NCBI Accession: NP_003872.1
Primary Accession: O76076
Other Accession: BC017782
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Other Names:
WNT1-inducible-signaling pathway protein 2, WISP-2, CCN family member 5, Connective tissue growth factor-like protein, CTGF-L, Connective tissue growth factor-related protein 58, WISP2, CCN5, CT58, CTGFL
Antigen Type:
Recombinant Protein
Gene Name: CCN5 (HGNC:12770)
Gene ID: 8839
NCBI Accession: NP_003872.1
Primary Accession: O76076
Other Accession: BC017782
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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