WNT3 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP14130c
Background:
The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 98% amino acid identity to mouse Wnt3protein, and 84% to human WNT3A protein, another WNT gene product.The mouse studies show the requirement of Wnt3 in primary axisformation in the mouse. Studies of the gene expression suggest thatthis gene may play a key role in some cases of human breast,rectal, lung, and gastric cancer through activation of theWNT-beta-catenin-TCF signaling pathway. This gene is clustered withWNT15, another family member, in the chromosome 17q21 region.
Other Names:
Proto-oncogene Wnt-3, Proto-oncogene Int-4 homolog, WNT3, INT4
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14130c was selected from the Center region of WNT3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: WNT3
Gene ID: 7473
Primary Accession: P56703
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 98% amino acid identity to mouse Wnt3protein, and 84% to human WNT3A protein, another WNT gene product.The mouse studies show the requirement of Wnt3 in primary axisformation in the mouse. Studies of the gene expression suggest thatthis gene may play a key role in some cases of human breast,rectal, lung, and gastric cancer through activation of theWNT-beta-catenin-TCF signaling pathway. This gene is clustered withWNT15, another family member, in the chromosome 17q21 region.
Other Names:
Proto-oncogene Wnt-3, Proto-oncogene Int-4 homolog, WNT3, INT4
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14130c was selected from the Center region of WNT3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: WNT3
Gene ID: 7473
Primary Accession: P56703
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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