WRN Antibody (Center T802) Blocking peptide
€363.00
In stock
SKU
AC-BP12078c
Background:
This gene encodes a member of the RecQ subfamily and theDEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNAhelicases are involved in many aspects of DNA metabolism, includingtranscription, replication, recombination, and repair. This proteincontains a nuclear localization signal in the C-terminus and showsa predominant nucleolar localization. It possesses an intrinsic 3'to 5' DNA helicase activity, and is also a 3' to 5' exonuclease.Based on interactions between this protein and Ku70/80 heterodimerin DNA end processing, this protein may be involved in the repairof double strand DNA breaks. Defects in this gene are the cause ofWerner syndrome, an autosomal recessive disorder characterized bypremature aging.
Other Names:
Werner syndrome ATP-dependent helicase, DNA helicase, RecQ-like type 3, RecQ3, Exonuclease WRN, 31--, RecQ protein-like 2, WRN, RECQ3, RECQL2
Gene Name: WRN
Gene ID: 7486
Primary Accession: Q14191
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a member of the RecQ subfamily and theDEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNAhelicases are involved in many aspects of DNA metabolism, includingtranscription, replication, recombination, and repair. This proteincontains a nuclear localization signal in the C-terminus and showsa predominant nucleolar localization. It possesses an intrinsic 3'to 5' DNA helicase activity, and is also a 3' to 5' exonuclease.Based on interactions between this protein and Ku70/80 heterodimerin DNA end processing, this protein may be involved in the repairof double strand DNA breaks. Defects in this gene are the cause ofWerner syndrome, an autosomal recessive disorder characterized bypremature aging.
Other Names:
Werner syndrome ATP-dependent helicase, DNA helicase, RecQ-like type 3, RecQ3, Exonuclease WRN, 31--, RecQ protein-like 2, WRN, RECQ3, RECQL2
Gene Name: WRN
Gene ID: 7486
Primary Accession: Q14191
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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