WT1 (clone 5G11A5), anti-human
€0.00
In stock
SKU
BT-MCA3331
Catalog Number: BT-MCA3331
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s): FCM
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s): FCM
Datasheet
Request Information
Background:
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Research Area: Epigenetics and nuclear signaling, Developmental biology, Cancer, Tags & cell markers
Synonyms: GUD, AWT1, WAGR, WT33, NPHS4, WIT-2, EWS-WT1
Immunogen: Purified recombinant fragment of human WT1 (AA: 314-479) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide.
Storage:
4°C|-20°C for long term storage
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Research Area: Epigenetics and nuclear signaling, Developmental biology, Cancer, Tags & cell markers
Synonyms: GUD, AWT1, WAGR, WT33, NPHS4, WIT-2, EWS-WT1
Immunogen: Purified recombinant fragment of human WT1 (AA: 314-479) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide.
Storage:
4°C|-20°C for long term storage
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