WWOX (phospho Tyr33) Polyclonal Antibody
€0.00
In stock
SKU
ELK-ES6561
Catalog Number: ELK-ES6561
Reactivity: Human, Mouse
Applications: WB, IHC-p, ELISA
Information
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Reactivity: Human, Mouse
Applications: WB, IHC-p, ELISA
Information
Request Manual ELK-
Questions? Contact us!
Background:
disease:Defects in WWOX may be involved in esophageal squamous cell carcinoma (ESCC) [MIM:133239].,disease:Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.,domain:The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1.,function:Probable oxidoreductase, which acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with TP53/p53 to control genotoxic stress-induced cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death.,PTM:Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,similarity:Contains 2 WW domains.,subcellular location:Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Isoform 5 and isoform 6 may localize in the nucleus.,subunit:Interacts with TP53, TP73/p73 and MAPK8. Interacts with MAPT/TAU (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. May interact with COTE1/C1orf2 and SCOTIN.,tissue specificity:Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.,
Alternative Names:
WWOX, FOR, WOX1, WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase
Immunogen: The antiserum was produced against synthesized peptide derived from human WWOX around the phosphorylation site of Tyr33. AA range:18-67
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Observed band: 55
GeneID: WWOX
Storage: -20°C/1 year
NOTE: For Research Use Only
disease:Defects in WWOX may be involved in esophageal squamous cell carcinoma (ESCC) [MIM:133239].,disease:Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.,domain:The WW 1 domain mediates interaction with TP53, and probably TP73, TFAP2C, LITAF and WBP1.,function:Probable oxidoreductase, which acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with TP53/p53 to control genotoxic stress-induced cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death.,PTM:Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,similarity:Contains 2 WW domains.,subcellular location:Partially localizes to the mitochondria. Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Isoform 5 and isoform 6 may localize in the nucleus.,subunit:Interacts with TP53, TP73/p73 and MAPK8. Interacts with MAPT/TAU (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. May interact with COTE1/C1orf2 and SCOTIN.,tissue specificity:Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.,
Alternative Names:
WWOX, FOR, WOX1, WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase
Immunogen: The antiserum was produced against synthesized peptide derived from human WWOX around the phosphorylation site of Tyr33. AA range:18-67
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Observed band: 55
GeneID: WWOX
Storage: -20°C/1 year
NOTE: For Research Use Only
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