WWTR1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71120
Background:
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex.
Alternative Name:
TAZ,WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: WWTR1 polyclonal antibody detects endogenous levels of WWTR1 protein.
Immunogen:
Recombinant protein of human WWTR1.
MW: ~ 44 kDa
Swis Prot.: Q9GZV5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex.
Alternative Name:
TAZ,WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: WWTR1 polyclonal antibody detects endogenous levels of WWTR1 protein.
Immunogen:
Recombinant protein of human WWTR1.
MW: ~ 44 kDa
Swis Prot.: Q9GZV5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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