X11γ (R401) polyclonal, anti-human
€305.00
In stock
SKU
BS3806
Background:
Amyloid β precursor protein (β APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The amyloid β precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid β precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β APP and slowing β APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β APP. Multiple splice varitents of X11 have been identified, including X11 α, β and γ (also known as Mint 1, 2 and 3, respectively).
Alternative Name:
Amyloid beta A4 precursor protein-binding family A member 3, Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3, Mint-3, APBA3, MINT3, X11L2
Application Dilution: IHC: 1:50~1:200
Specificity: X11γ (R401) polyclonal antibody detects endogenous levels of X11γ protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 371-420 of Human X11γ.
MW: ~ 61 kDa
Swis Prot.: O96018
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Amyloid β precursor protein (β APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The amyloid β precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid β precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β APP and slowing β APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β APP. Multiple splice varitents of X11 have been identified, including X11 α, β and γ (also known as Mint 1, 2 and 3, respectively).
Alternative Name:
Amyloid beta A4 precursor protein-binding family A member 3, Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3, Mint-3, APBA3, MINT3, X11L2
Application Dilution: IHC: 1:50~1:200
Specificity: X11γ (R401) polyclonal antibody detects endogenous levels of X11γ protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 371-420 of Human X11γ.
MW: ~ 61 kDa
Swis Prot.: O96018
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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