XBP1 antibody (clone 3F5), anti-human
€435.00
In stock
SKU
AC-AT4549a
Catalog Number: AC-AT4549a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF
Request Information AC-AT4549a">Request Information
Background:
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Other Names:
X-box-binding protein 1, XBP-1, Tax-responsive element-binding protein 5, XBP1, TREB5, XBP2
Antigen Type:
Recombinant Protein
Gene Name: XBP1 (HGNC:12801)
Gene ID: 7494
NCBI Accession: NP_001073007.1;NP_005071.2
Primary Accession: P17861
Other Accession: BC012841
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Other Names:
X-box-binding protein 1, XBP-1, Tax-responsive element-binding protein 5, XBP1, TREB5, XBP2
Antigen Type:
Recombinant Protein
Gene Name: XBP1 (HGNC:12801)
Gene ID: 7494
NCBI Accession: NP_001073007.1;NP_005071.2
Primary Accession: P17861
Other Accession: BC012841
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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