XPC (clone 5F4B11), anti-human

Background:
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Research Area: Epigenetics and nuclear signaling

Synonyms: XP3, RAD4, XPCC, p125

Immunogen: Purified recombinant fragment of human XPC (AA: 32-133) expressed in mammalian.

Formulation: Purified antibody in PBS with 0.05% sodium azide

Storage:
4°C|-20°C for long term storage