XRCC4 Monoclonal Antibody

Background:
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
DNA double strand break repair and V(D)J recombination protein XRCC4, DNA repair protein XRCC4, SSMED, X ray repair complementing defective repair in Chinese hamster cells 4, X ray repair cross complementing 4, X ray repair cross complementing protein 4, X-ray repair cross-complementing protein 4, XRCC 4, XRCC4, XRCC4

Immunogen: Synthetic Peptide

Swissprot: Q13426

Calculated MW: 38 kDa
Observed MW: 38 kDa

Purification Method: Protein A purification

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-136124/sc-365055/sc-365118